GCSE Biology Paper 2 – Complete Revision Guide

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Homeostasis & the Nervous System

  • Homeostasis: the ability of an organism to keep internal conditions stable despite external changes (e.g., blood glucose, temperature, water balance).
  • Nervous system split into CNS (brain + spinal cord) and PNS (all other nerves).
  • Receptor → sensory neuron → relay neuron → spinal cord → brain (conscious decision) → motor neuron → effector (muscle).
  • Reflex arc: signal bypasses the brain, travelling only through the spinal cord for a faster response.

Measuring Reaction Time

  • Drop a ruler from the thumb, record the distance before it is caught.
  • Convert distance to time (s = √(2d/g)).
  • Variables: stimulants (coffee) speed up, depressants slow down.

Brain Regions to Know

  • Cerebral cortex – memory, speech, problem solving.
  • Cerebellum – coordination, balance, motor skills.
  • Medulla – involuntary actions (breathing, heart rate) and adrenaline release.
  • MRI scans show brain activity non‑invasively.

The Eye & Vision

  • Accommodation – lens shape changes via ciliary muscles & suspensory ligaments.
  • Pupil size adjusts to light intensity.
  • Cornea refracts light; retina contains rods (light intensity) and cones (colour – red, green, blue).
  • Vision problems: myopia (far‑sightedness), hyperopia (near‑sightedness); corrected with glasses, contacts, or laser surgery.

Thermoregulation

  • Body temperature sensed by the brain → nervous & hormonal signals.
  • Too hot: sweat glands evaporate water, vasodilation increases blood flow to skin.
  • Too cold: vasoconstriction, shivering generates heat.

Endocrine System & Hormones

  • Glands release hormones into the bloodstream (slower than nerve signals).
  • Pituitary gland – master gland; controls thyroid, pancreas, adrenal, gonads.
  • Pancreas: insulin lowers blood glucose; glucagon raises it.
  • Diabetes types: Type 1 (no insulin production) and Type 2 (cells resistant to insulin).

Water Balance & Kidneys

  • Water lost via breath, sweat, urine.
  • Kidneys filter blood, re‑absorb glucose & ions, excrete excess water as urine.
  • ADH (antidiuretic hormone) from pituitary tells kidneys how much water to re‑absorb – classic negative feedback loop.
  • Dialysis replaces kidney function when kidneys fail.

Reproduction, Menstruation & Contraception

  • FSH → egg maturation & estrogen production → uterine lining thickens.
  • LH triggers ovulation; progesterone maintains lining.
  • Contraception options: hormonal pills, injections, implants, condoms, diaphragms, IUDs, tubal ligation, vasectomy.
  • Infertility can be treated with hormone therapy or IVF (in‑vitro fertilisation).

Plant Hormones

  • Gibberellins: seed germination, flowering, fruit size.
  • Ethylene: fruit ripening.
  • Auxins: phototropism (bends toward light) & root geotropism (grow downwards).
  • Applications: rooting powders, weed control, tissue‑culture growth.

Cell Division & Genetics

  • Meiosis produces four haploid gametes → genetic variation.
  • Mitosis creates identical diploid cells (asexual reproduction).
  • DNA: double helix of nucleotides (A‑T, C‑G). Every three bases code for an amino acid.
  • Gene expression → protein → phenotype.
  • Dominant vs recessive alleles; homozygous vs heterozygous; Punnett squares predict offspring ratios.
  • Human genome: 23 chromosome pairs; sex chromosomes (XX female, XY male).

Evolution & Antibiotic Resistance

  • Darwin: random variation + natural selection.
  • Lamarck: acquired traits (now linked to epigenetics).
  • Antibiotic resistance arises from mutation & selection – complete courses are essential.

Classification & Taxonomy

  • Hierarchy: Domain, Kingdom, Phylum, Class, Order, Family, Genus, Species.
  • Mnemonic: “King Philip Came Over For Good Soup”.
  • Domains: Archaea (extremophiles), Bacteria, Eukarya.

Ecosystems, Energy Flow & Biodiversity

  • Abiotic factors: light, temperature, moisture, pH, CO₂, O₂.
  • Biotic factors: food, predators, competitors, pathogens.
  • Quadrats & transects estimate population size & distribution.
  • Food chain levels: producers → primary consumers → secondary → tertiary → apex predators.
  • Biomass pyramids illustrate energy loss at each trophic level.
  • High biodiversity → ecosystem stability; human development often reduces it.

Environmental Challenges & Food Security

  • Deforestation, peat‑bog loss, pollution, waste management threaten biodiversity.
  • Sustainable fishing uses mesh sizes that let juveniles escape.
  • Food security pressures: growing population, climate change, conflict (e.g., Ukraine wheat supply).
  • Strategies: improve crop yields, reduce waste, adopt sustainable practices.

Genetic Engineering & Cloning

  • Gene cutting (restriction enzymes) → vector (plasmid/virus) → insertion into target organism.
  • Applications: insulin‑producing bacteria, Golden Rice (vitamin A), disease‑resistant crops.
  • Cloning: plant cuttings, tissue culture, animal somatic‑cell nuclear transfer (e.g., Dolly the sheep).

Fossils & Evolutionary Evidence

  • Fossils can be mineralised bones, footprints, or trace fossils.
  • Provide historical record of life and evolutionary change.

This guide covers every major topic required for GCSE Biology Paper 2, from cellular processes to ecosystem dynamics, giving you a concise yet comprehensive revision resource.

Mastering the interconnected systems of the human body, genetics, and ecosystems—and understanding how they are regulated—provides the foundation needed to excel in GCSE Biology Paper 2.

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